A report of a family with an MSH2 mutation and prostate cancer
نویسندگان
چکیده
Background There have been conflicting reports regarding the possibility of an association between Lynch syndrome and prostate cancer. Some reports indicate that individuals with mismatch repair gene mutations may be at an increased risk of prostate cancer, while others show little to no evidence of an association. We are reporting a family with multiple cancers including colorectal, endometrial, ovarian, brain, skin and prostate.
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The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries prostate cancer is the second common cancer (after skin cancer), and also the second leading cause of cancer death (after lung cancer) among men. The several studies have been shown prostate cancer familial aggregation. The main reason for this aggregation is inheritance included genes....
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T he question of whether men with an inherited genetic condition called Lynch syndrome have an increased risk of developing prostate cancer has been controversial. It is important to answer this question, for understanding the role of DNA mismatch repair in carcinogenesis of prostate as well as for clinical implications for screening. Lynch syndrome, previously known as hereditary non-polyposis...
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